Two species of hornworm caterpillars feed on tobacco and other plants. Tobacco hornworms (Manduca sexta) and tomato hornworms (Manduca quinquemaculata) are easy to confuse. They both have similar appearance, life cycles, and eat some of the same host plants. Mature caterpillars of either of these pests can quickly defoliate tobacco and tomato plants. We made a video that describes their lifecycle and illustrates key characters to tell these two species apart.